Open Access, Peer-reviewed

ISSN 2005-7571 (Online)
Volume 25, Number 1 (1/2018)
Review Article <page. 1-8 >

The Roles of Frontal Cortex in Primary Insomnia : Findings from Functional Magnetic Resonance Imaging Studies

Bori Kim, PhD1;Su Hyun Park1;Han Byul Cho, PhD2; and Jungyoon Kim, MD1,2;

1;Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, 2;Ewha Brain Institute, Ewha Womans University, Seoul, Korea

Insomnia is a common sleep-related symptom which occurs in many populations, however, the neural mechanism underlying insomnia is not yet known. The hyperarousal model explains the neural mechanism of insomnia to some extent, and the frontal cortex dysfunction has been known to be related to primary insomnia. In this review, we discuss studies that applied resting state and/or task-related functional magnetic resonance imaging to demonstrate the deficits/dysfunctions of functional activation and network in primary insomnia. Empirical evidence of the hyperarousal model and proposed relation between the frontal cortex and other brain regions in primary insomnia are examined. Reviewing these studies could provide critical insights regarding the pathophysiology, brain network and cerebral activation in insomnia and the development of novel methodologies for the diagnosis and treatment of insomnia.

Key words : Sleep;Primary insomnia;fMRI;Frontal cortex;Functional connectivity.


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