Open Access, Peer-reviewed

ISSN 2005-7571 (Online)
Volume 13, Number 2 (2/2006)
Original Article <page. 103-9 >

Interactions of Vascular Risk Factors and Apolipoprotein E4 on Geriatric Depression

Hye-Young Park, MD, PhD1;Jae-Min Kim, MD, PhD1,2;Il-Seon Shin, MD, PhD1,2;Su-Jin Yang, MD, PhD1,2;Sung-Wan Kim, MD, PhD1,2;Seon-Young Kim, MD1;Hee-Young Shin, MD, PhD2,3; and Jin-Sang Yoon, MD, PhD1,2,3;

1;Department of Psychiatry, Chonnam National University Medical School, Gwangju, 2;Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, 3;Clinical Trial Center, Chonnam National University Hospital, Gwangju, Korea

ObjectiveAssociations of vascular risk/disease or apolipoprotein E ε4(APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk/disease and APOE4 on depression in a Korean elderly population.

Methods:732 community residents aged 65 or over were assessed for depression(GMS), information on vascular risk/disease(reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk/disease(blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics(age, gender, education), physical health, and cognitive function(MMSE).

Results:Previous stroke and lower level of high density lipoprotein(HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didn't reach to statistical significance.

Conclusion:Associations between vascular risk/disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.

Key words : Stroke;Vascular risk;Apolipoprotein E;Depression;Elderly.


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