ISSN 1225-8709 (Print)
ISSN 2005-7571 (Online)
Volume 25, Number 2 (2/2018)
Review Article <page. 21-30 >

Association between the Brain-Derived Neurotropic Factor and Attention Deficit Hyperactivity Disorder

Na Ri Kang, MD1;Jae Min Song, MD2; and Young-Sook Kwack, MD1,3;

1lDepartment of Psychiatry, Jeju National University Hospital, Jeju, 2;Department of Psychiatry, Jeju Medical Center, Jeju, 3;Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea

Attention deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder. Recently, it has been suggested that brain-derived neurotropic factor (BDNF) may play a role in the pathogenesis of ADHD. Our aim of this review is to understand the physiological functions of BDNF and its potential relationship with ADHD and therapeutic approaches of ADHD. Searches were conducted in Pubmed and Research Information Service System (RISS). In this review, we summarized important literatures for the physiological functions of BDNF in neurodevelopment, change of serum BDNF level in ADHD, association of BDNF polymorphism and ADHD and potential association of treatment of ADHD with serum BDNF level. Further studies are required to more clearly understand the source and the role of BDNF in ADHD and to develop BDNF based-ADHD treatement.

Key words : Brain-derived neurotropic factor (BDNF);Attention deficit hyperactivity disorder (ADHD).


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