ISSN 1225-8709 (Print)
ISSN 2005-7571 (Online)
Volume 24, Number 4 (4/2017)
Original Article <page. 219-24 >

The Alteration of % Carbohydrate-Deficient Transferrin and Gamma-Glutamyl Transferase Levels of Alcohol-Dependent Inpatients according to Age and Sex

Gyo-Sik Jin, MD1;Jung Seo Yi, MD1;Boung Chul Lee, MD2;Jee Wook Kim, MD3; and Ihn-Geun Choi, MD1;

1;Department of Neuropsychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 2;Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 3;Department of Neuropsychiatry, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea

Objectives : This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence.

Methods : The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT).

Results : Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients.

Conclusions : These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.


Key words : Alcohol dependence;Age;Sex;Carbohydrate-deficient transferrin;Gamma-glutamyl transferase.

PSYCHIATRY INVESTIGATION

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