ISSN 1225-8709 (Print)
ISSN 2005-7571 (Online)
Volume 24, Number 3 (3/2017)
Review Article <page. 95-109 >

Clinical Efficacy of Repetitive Transcranial Magnetic Stimulation for Treatment of Depression and Latest Trends in TMS Techniques

Shin Tae Kim, BA1;Hae Won Kim, MD2,3;Se Joo Kim, MD2,3; and Jee In Kang, MD2,3;

1;Yonsei University College of Medicine, Seoul, 2;Department of Psychiatry, Yonsei University College of Medicine, Seoul, 3;Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique which can change cortical excitability in targeted area by producing magnetic field pulses with an electromagnetic coil. rTMS treatment has been used to treat various neuropsychiatric disorders including depression. In this review, we evaluate the literature on rTMS for depression by assessing its efficacy on different subtypes of depression and different technical parameters. In particular, we focus on the results of randomized clinical trials and meta-analyses for depression after the US Food and Drug Administration approval in 2008, which acknowledged its efficacy and acceptability. We also review the new forms of rTMS therapy including deep TMS, theta-burst stimulation, and magnetic seizure therapy (MST) that have been under recent investigation. High frequency rTMS over left dorsolateral prefrontal cortex (DLPFC), low frequency rTMS over right DLPFC, or bilateral rTMS is shown to be effective and acceptable in treatment for patients with non-psychotic, unipolar depression either as monotherapy or adjuvant. Deep TMS, theta-burst stimulation and MST are promising new TMS techniques which warrant further research.


Key words : Efficacy;Safety;Depression;Repetitive transcranial magnetic stimulation;Brain stimulation techniques.

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